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Foliglurax monohydrochloride(PXT002331(monohydrochloride))
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Foliglurax monohydrochloride(PXT002331(monohydrochloride))图片
CAS NO:2133294-96-7
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Foliglurax monohydrochloride (PXT002331 (monohydrochloride)) (PXT002331 monohydrochloride) 是一种高选择性和有效的脑渗透性代谢型谷氨酸受体 4 正变构调节剂 (mGluR4 PAM)，EC50 为 79 nM。
Cas No.2133294-96-7
别名PXT002331 (monohydrochloride)
Canonical SMILESO/N=C1C=C(C2=NC=C(C=CS3)C3=C2)OC4=C\1C=CC(CCCN5CCOCC5)=C4.Cl
分子式C23H24ClN3O3S
分子量457.97
溶解度DMSO : 5 mg/mL (10.92 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Foliglurax monohydrochloride (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant mGluR4 positive allosteric modulator (PAM), with an EC50 of 79±19 nM[1]. Antiparkinsonian effect[1].

Foliglurax, a highly selective and potent mGlu4 receptor PAM with a marked brain-penetrance feature, might revolutionize the field of mGlu4 receptor drug targeting in CNS disorders[2].

[1]. Charvin D, et al. Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4. J Med Chem. 2017 Oct 26;60(20):8515-8537. [2]. Volpi C, et al. Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4. Expert Opin Drug Discov. 2018 May;13(5):411-423.