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1,3,7-Trimethyluric Acid
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
1,3,7-Trimethyluric Acid图片
CAS NO:5415-44-1
包装与价格：
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍
1,3,7-三甲基尿酸是咖啡因的代谢物。可以评估 1,3,7-三甲基尿酸与咖啡因的代谢比率作为生物标志物来描述队列中 CYP3A 活性的变异性。
Cas No.5415-44-1
别名1,3,7-三甲基尿酸,8-oxo Caffeine, NSC 11259
化学名7,9-dihydro-1,3,7-trimethyl-1H-purine-2,6,8(3H)-trione
Canonical SMILESO=C(N1)N(C)C2=C1N(C)C(N(C)C2=O)=O
分子式C8H10N4O3
分子量210.2
溶解度DMF: 5 mg/ml,DMSO: 20 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

1,3,7-Trimethyluric acid is a methyl derivative of uric acid and a product of C-8 oxidation of caffeine by cytochrome P450 enzymes. It can be detected in urine as a marker of caffeine consumption.

Reference:
[1]. Tassaneeyakul, W., Birkett, D.J., McManus, M.E., et al. Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms. Biochem. Pharmacol. 47(10), 1767-1776 (1994).
[2]. Bhat, V.B., Sridhar, G.R., and Madyastha, K.M. Efficient scavenging of hydroxyl radicals and inhibition of lipid peroxidation by novel analogues of 1,3,7-trimethyluric acid. Life Sci. 70(4), 381-393 (2001).