MCT1-IN-2 is a potentmonocarboxylate transporter1 (MCT1)inhibitor. MCT1-IN-2 has anti-cancer activity^[1][2].

MCT1-IN-2 (compound 3) has a pK_iof 9.48 for Jurkat T-cells and inhibits human peripheral blood mononuclear cells (PBMC) proliferation (pIC₅₀=8.61)^[1].
MCT1-IN-2 (compound 1) has an EC₅₀of 5.5 nM (MTT assay) and an IC₅₀of 105 nM (lactate transport inhibition assay) in human Raji lymphoma cell proliferation^[2].

435.58

Solid

C₂₅H₂₉N₃O₂S

227321-12-2

Room temperature in continental US; may vary elsewhere.