JMS-17-2 hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2341841-07-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

JMS-17-2 hydrochloride 是一种有效的选择性CX3CR1拮抗剂，IC₅₀为 0.32 nM。JMS-17-2 hydrochloride 降低乳腺癌细胞的转移和定植。

生物活性

JMS-17-2 hydrochloride is a potent and selectiveCX3CR1antagonist with anIC₅₀of 0.32 nM. JMS-17-2 hydrochloride impairs metastatic seeding and colonization of breastcancercells^[1].

IC₅₀& Target

IC50: 0.32 nM (CX3CR1)^[1]

体内研究
(In Vivo)

JMS-17-2 (10 mg/kg; aministered i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice^[1].

Animal Model:	SCID mice (~25g) with MDA-231 xenograft^[1]
Dosage:	10 mg/kg
Administration:	Aministered i.p.; twice a day for three weeks
Result:	Caused a dramatic reduction of tumors in both skeleton and visceral organs.

分子量

456.41

Formula

C₂₅H₂₇Cl₂N₃O

CAS 号

2341841-07-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.