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D-Proline,4-hydroxy-,methyl ester hydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
D-Proline,4-hydroxy-,methyl ester hydrochloride图片
CAS NO:114676-59-4
包装与价格：
包装价格(元)
500mg电议
1g电议

产品介绍
D-Proline, 4-hydroxy-, methyl ester (hydrochloride) 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联药物 (ADCs)。D-Proline, 4-hydroxy-, methyl ester (hydrochloride) 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。
Cas No.114676-59-4
分子式C6H12ClNO3
分子量181.62
储存条件4°C, away from moisture
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

D-Proline, 4-hydroxy-, methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). D-Proline, 4-hydroxy-, methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].