PAD2-IN-1 hydrochloride, a benzimidazole-based derivative, is a potent and selectiveprotein arginine deiminase2 (PAD2)inhibitor. PAD2-IN-1 hydrochloride shows superior selectivity forPAD2over PAD4 (95-fold) and PAD3 (79-fold)^[1].

Protein Arginine Deiminase 2 (PAD2)^[1]

In the target engagement assay, the EC₅₀of PAD2-IN-1 (compound 32a) hydrochloride is 8.3 μM in HEK293T/PAD2 cells, the enhanced potency of PAD2-IN-1 overcomes its relatively poor ability to enter cells^[1].
PAD2-IN-1 (compound 32a; 1-25 μM) hydrochloride treatment strongly inhibits histone H3 citrullination with an EC₅₀of 2.7 μM in HEK293T/PAD2 cells^[1].

517.00

Solid

C₂₅H₃₀ClFN₆O₃

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)