MPI-0479605 is a potent and selective ATP-competitive inhibitor ofMps1, with anIC₅₀of 1.8 nM.

MPI-0479605 is a potent and selective ATP-competitive inhibitor of Mps1, with an IC₅₀of 1.8 nM. MPI-0479605 (0.1-10 μM) reduces cell viability of HCT-116 cells in a dose-dependent manner. MPI-0479605 shows severe defects in the ability to align chromosomes at the metaphase plate, but causes complete cytokinesis^[1].

MPI-0479605 (30 mg/kg daily or 150 mg/kg every fourth day (Q4D), i.p.) inhibits tumor growth by 49% and 74 % in HCT-116 xenografts. However, MPI-0479605 does not show inhibitory activity via daily dosing on the Colo-205 xenografts, and dosing every four days causes 63% tumor growth inhibition (TGI)^[1].

407.51

Solid

C₂₂H₂₉N₇O

1246529-32-7

Room temperature in continental US; may vary elsewhere.

DMSO : 11 mg/mL(26.99 mM;Need ultrasonic and warming)

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