Theophylline (1,3-Dimethylxanthine) sodium glycinate is a potentphosphodiesterase (PDE)inhibitor,adenosine receptorantagonist, andhistone deacetylase (HDAC)activator. Theophylline sodium glycinate inhibitsPDE3activity to relax airway smooth muscle. Theophylline sodium glycinate has anti-inflammatory activity by increaseIL-10and inhibitNF-κBinto the nucleus. Theophylline sodium glycinate inducesapoptosis. Theophylline sodium glycinate can be used for asthma and chronic obstructive pulmonary disease (COPD) research^{[1][2][3][4][5]}.

Theophylline sodium glycinate (1-1000 μM) inhibits cAMP hydrolysis by PDE in homogenates of bronchial tissue to relax human bronchus and pulmonary arteries^[1].
Theophylline sodium glycinate (10 μg/mL; 24 h) induces apoptosis through a reduction in the antiapoptotic protein Bcl-2 in eosinophils^[2].
Theophylline sodium glycinate (0-500 μM; 2 h) inhibits NF-κB activation, I kappa B alpha (I-κBα) degradation and decreases the level of IL-6 in a concentration-dependent manner^[3].
Theophylline sodium glycinate (0-1000 μM; 30 min; A549 cells) induces histone deacetylase activity to decrease inflammatory gene expression^[4].

Theophylline sodium glycinate (100 mg/kg; i.p.; daily, for 9 d) has anti-inflammatory activity in mice and increases IL-6 and IL-10 levels and inhibits TNF-α and NO in male Swiss mice^[1].

278.22

C₉H₁₃N₅NaO₄⁺

8000-10-0

茶碱甘氨酸钠

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.