DKFZ-748

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DKFZ-748

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2490709-68-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

DKFZ-748 是一种选择性的HDAC10抑制剂 (pIC₅₀=7.66)，并具有出抗肿瘤活性。

生物活性

DKFZ-748 is a selectiveHDAC10inhibitor (pIC₅₀=7.66), and shows anti-tumor activity^[1].

体外研究
(In Vitro)

DKFZ-748 shows dose-dependent growth inhibition of HeLa cells in a polyamine-limiting in vitro tumor model^[1].
DKFZ-748 (1-100 μM; 72 h) induces HDAC acetylation of BE(2)-C cells^[1].
DKFZ 748 shows significant accumulation of N8 acetyl- and N1,8-diacetylspermidine in a dose-dependent manner^[1].

Western Blot Analysis^[1]

Cell Line:	BE(2)-C cells
Concentration:	1, 10, 100 μM
Incubation Time:	72 h
Result:	Induced significant HDAC acetylation only at the highest tested concentration (100 μM).

分子量

329.39

Formula

C₁₈H₂₃N₃O₃

CAS 号

2490709-68-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.