GSK2983559 is an orally active and potentreceptor interacting protein 2(RIP2) kinase inhibitor. GSK2983559 blocks many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples^[1].

GSK2983559 (1-1024 nM; 2 h) blocks MDP-induced IL-8 in THP-1 cells^[2].

GSK2983559 (oral gavage; 3 and 10 mg/kg; once) inhibits effectively MDP-induced IL-6 in mouse^[2].

611.61

Solid

C₂₁H₂₈CaN₄O₁₀PS₂⁺

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

H₂O : 2 mg/mL(3.27 mM;Need ultrasonic)

DMSO :< 1 mg/mL (ultrasonic;warming;heat to 80℃)(insoluble or slightly soluble)

DMF :< 1 mg/mL (ultrasonic;warming;heat to 80℃)(insoluble)

Ethanol :< 1 mg/mL (ultrasonic)(insoluble)

*GSK2983559 is usually formulated as a suspension.

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。