HS56

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HS56

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

922050-57-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

HS56 是一种 ATP 竞争性Pim/DAPK3双重抑制剂，对 DAPK3、Pim-3、Pim-1和 Pim-2 的K_i值分别为 0.26、0.208、2.94 和＞100 μM。 HS56 抑制 LC20 磷酸化和平滑肌收缩。HS56 降低自发性高血压小鼠的血压。HS56可用于高血压研究。

生物活性

HS56 is an ATP-competitive dualPim/DAPK3inhibitor withK_ivalues of 0.26, 0.208, 2.94, and ＞100 μM for DAPK3, Pim-3, Pim-1, and Pim-2, respectively. HS56 inhibits LC20 phosphorylation and smooth muscle contraction. HS56 decreases blood pressure in spontaneously hypertensive mice. HS56 can be used in research of hypertension^[1].

IC₅₀& Target^[1]

PIM3

0.208 μM (Ki)

PIM1

2.94 μM (Ki)

PIM2

＞100 μM (Ki)

体外研究
(In Vitro)

HS56 (50 μM; 16 h) 延迟离体大鼠尾动脉 VSM 组织中的力开始，降低收缩力，并降低 LC20 磷酸化^[1]。

Western Blot Analysis^[1]

Cell Line:	VSM tissues
Concentration:	50 μM
Incubation Time:	16 hours
Result:	Modulated LC20 phosphorylation in VSM tissues.

体内研究
(In Vivo)

HS56 (10 and 20 mg/kg; i.v.; 单次注射) 降低自发性高血压小鼠的血压 (BP)^[1]。

Animal Model:	Spontaneously hypertensive renin transgene and wild-type (WT) mice^[1]
Dosage:	10 and 20 mg/kg
Administration:	Intravenous injection, single injection
Result:	Induced dose-dependent decreases in systolic blood pressure.

分子量

317.75

Formula

C₁₃H₈ClN₅OS

CAS 号

922050-57-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.