Polatuzumab vedotin

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Polatuzumab vedotin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	1313206-42-6
包装:	1mg
市场价:	11500元

产品介绍

Polatuzumab vedotin 是一种靶向 CD79b 的抗体药物偶联物。它由一种人源化抗 CD79b IgG1 单克隆抗体与一种有效的微管抑制剂单甲基 auristatin E (MMAE) 相连，是一种有效的微管抑制剂。Polatuzumab vedotin 具有研究大 B 细胞淋巴瘤 (LBCL) 的潜力。

生物活性

Polatuzumab vedotin is an antibody-drug conjugate targeting CD79b. It contains a humanized anti-CD79bIgG1monoclonal antibody linked to monomethylauristatinE (MMAE), a potent microtubule inhibitor. Polatuzumab vedotin has the potential for the research of Large B-cell lymphomas (LBCL)^[1].

体内研究
(In Vivo)

Polatuzumab vedotin (0.3, 1, 3, 6, 12 mg/kg; i.v.; once) shows anti-tumor in a mouse tumour xenograft model of human diffuse large B‐cell lymphoma WSU‐DLCL2^[2].

Animal Model:	SCID mice (human diffuse large B-cell lymphoma WSU-DLCL2)^[2]
Dosage:	0.3, 1, 3, 6, 12 mg/kg
Administration:	I.v.; once
Result:	Showed dose-dependent tumour growth inhibition.

CAS 号

1313206-42-6

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.