[登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > Relatlimab
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Relatlimab
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAS NO:1673516-98-7
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
Relatlimab (BMS-986016) 是一种人单克隆抗体抗 LAG-3 抗体，由携带重组 LAG-3 蛋白的人免疫球蛋白的转基因小鼠免疫生成。Relatlimb 阻断了 LAG-3/MHC II 的相互作用，其 IC50 值为 0.67 nM，以及阻断了 LAG-3/FGL1 的相互作用，其 IC50 值为 0.019 nM。Relatlimab 可用于癌症的研究。
Cas No.1673516-98-7
别名BMS-986016
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Relatlimab (BMS-986016) is a human monoclonal antibodyanti-LAG-3antibody generated by immunization of transgenic mice bearing human immunoglobulin miniloci with recombinant LAG-3 protein. Relatlimab blocks LAG-3/MHC II interaction with anIC50value of 0.67 nM and LAG-3/FGL1 interaction with anIC50value of 0.019 nM. Relatlimab can be used in research of cancer[1].

Relatlimab (BMS-986016; 0.001-100 nM) recognizes native LAG-3 and binds to primary activated human and cynomolgus CD4+ T cells with EC50values of 0.11 nM and 29.11 nM, respectively[1].
Relatlimab (0.001-10000 nM; T cells (3A9-hLAG-3)) enhances peptide responsiveness of T-cell hybridoma 3A9-hLAG-3 and reversals LAG-3-mediated inhibition of T-cell hybridoma 3A9-hLAG-3 with an IC50value of 1.05 nM[1].
Relatlimab (0.001-10000 nM; primary T cells) enhances activation of superantigen-stimulated human PBMC cultures and enhances IL-2 secretion[1].