Triflurdine(Viroptic)

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

70-00-8

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	电议
50mg	电议

产品介绍

Triflurdine (Viroptic) (Trifluorothymidine; 5-Trifluorothymidine; TFT) 是一种不可逆的胸苷酸合成酶抑制剂，从而抑制 DNA 合成。 Triflurdine (Viroptic) 是一种用于单纯疱疹病毒 (HSV) 感染的抗病毒药物。三氟胸苷还具有抗正痘病毒活性。

Cas No.	70-00-8
别名	曲氟尿苷; Trifluorothymidine; 5-Trifluorothymidine; TFT
化学名	1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)pyrimidine-2,4-dione
Canonical SMILES	C1C(C(OC1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O
分子式	C₁₀H₁₁F₃N₂O₅
分子量	296.2
溶解度	≥ 14.45mg/mL in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Trifluridine (Trifluorothymidine; 5-Trifluorothymidine; TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral drug for herpes simplex virus (HSV) infection. References: [1]. Suzuki N, et al. Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes. Int J Oncol. 2011 Jul;39(1):263-70. [2]. Suzuki N, et al. Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks. Exp Ther Med. 2011 May;2(3):393-397. [3]. Temmink OH, et al. Irinotecan-induced cytotoxicity to colon cancer cells in vitro is stimulated by pre-incubation withtrifluorothymidine. Eur J Cancer. 2007 Jan;43(1):175-83. [4]. Okayama T, et al. Involvement of concentrative nucleoside transporter 1 in intestinal absorption of trifluorothymidine, a novel antitumor nucleoside, in rats. J Pharmacol Exp Ther. 2012 Feb;340(2):457-62.