Spermine

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Spermine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

71-44-3

包装与价格：

包装	价格(元)
1g	电议
5g	电议
10g	电议
25g	电议

产品介绍

化学性质

Physical Appearance	A neat oil
Storage	Store at -20°C
M.Wt	202.3
Cas No.	71-44-3
Formula	C₁₀H₂₆N₄
Synonyms	Gerontine,Musculamine,Neuridine,NSC 268508,1,5,10,14-Tetraazatetradecane
Solubility	≥37.6 mg/mL in DMSO; ≥43.5 mg/mL in EtOH; ≥47.5 mg/mL in H2O
Chemical Name	N¹,N⁴-bis(3-aminopropyl)-1,4-butanediamine
Canonical SMILES	NCCCNCCCCNCCCN
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Spermine is an endogenous polyamine involved in cellular metabolism found in all eukaryotic cells. Spermine is required for eukaryotic cell growth and protein synthesis. Spermine functions as physiological blockers of inward rectifier K+ channels [1].

Inward rectifier K+ channels mediate the K+ conductance at resting potential in many types of cell. Inward rectifier K+ channels play an important role in controlling excitability [1].

Spermine blocked cloned inward rectifier K+ channels IRK1 with the IC50 of 31 nM clamped at 50 mV membrane potential [1]. Physiological concentrations of free spermine (10 μM) mediated strong rectification of IRK1 inward rectifier K+ channels even in the absence of free Mg2+ and in IRK1 mutant channels that have no endogenous rectification [1].

High dose level of spermine induced a great number of changes, such as emaciation, aggressiveness, convulsions and paralysis of the hind legs in Wistar rats. Spermine considerably decreased growth, food intake and water intake [3].

References:
[1] Fakler B, Brndle U, Glowatzki E, et al. Strong voltage-dependent inward rectification of inward rectifier K+ channels is caused by intracellular spermine[J]. Cell, 1995, 80(1): 149-154.
[2] Til H P, Falke H E, Prinsen M K, et al. Acute and subacute toxicity of tyramine, spermidine, spermine, putrescine and cadaverine in rats[J]. Food and Chemical Toxicology, 1997, 35(3): 337-348.