[登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > Calcium Ionophore I
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Calcium Ionophore I
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Calcium Ionophore I图片
CAS NO:58801-34-6
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
钙离子载体 I (ETH 1001) 是一种用于生物膜的选择性 Ca2+ 离子载体。
Cas No.58801-34-6
别名钙离子载体,ETH 1001
化学名(17R,18R)-diethyl 13,17,18,22-tetramethyl-14,21-dioxo-16,19-dioxa-13,22-diazatetratriacontane-1,34-dioate
Canonical SMILESC[C@H]([C@H](OCC(N(CCCCCCCCCCCC(OCC)=O)C)=O)C)OCC(N(C)CCCCCCCCCCCC(OCC)=O)=O
分子式C38H72N2O8
分子量684.99
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Calcium Ionophore I, also known as CA 1001 or ETH 1001, is a Ca2+-selective ionophore [1][2].

Ionophores can selectively change the ionic permeability of a membrane and therefore can be used to mimic the properties of the ion carriers normally found in biological membranes and to study membrane function [2].

Calcium Ionophore I is a Ca2+-selective neutral carrier. In Ca2+ loaded IOVs derived from human RBCs, ETH 1001 promoted Ca2+ flux across RBC membranes. The amount of Ca2+ in cells treated with ETH 1001 was significantly higher than in control cells. In the presence of external Ca2+, ETH 1001 was capable of transporting Ca2+ into RBCs [3]. CA 1001 was also used to construction of the Ca2+-selective membrane microelectrode [4][5].

References:
[1]Dagostino M, Lee CO. Neutral carrier Na+- and Ca2+-selective microelectrodes for intracellular application. Biophys J. 1982 Dec;40(3):199-207.
[2]Caroni P, Gazzotti P, Vuilleumier P, et al. Ca2+ transport mediated by a synthetic neutral Ca2+ -ionophore in biological membranes. Biochim Biophys Acta. 1977 Nov 1;470(3):437-45.
[3]Hinds TR, Vincenzi FF. The effect of ETH 1001 on ion fluxes across red blood cell membranes. Cell Calcium. 1985 Jun;6(3):265-79.
[4]Lücke A, Lehmenkühler A, Speckmann EJ. The influence of the convulsant pentylenetetrazol on Ca2+-selective microelectrodes (neutral carrier ETH 1001). J Neurosci Methods. 1989 Aug;29(2):139-42.
[5]Lee MH, Yoo CL, Lee JS, et al. Tweezer-type neutral carrier-based calcium-selective membrane electrode with drastically reduced anionic interference. Anal Chem. 2002 Jun 1;74(11):2603-7.