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IAA-94
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
IAA-94图片
CAS NO:54197-31-8
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
10mg电议
50mg电议

产品介绍
IAA-94 (R(+)-Methylindazone) 是一种有效的上皮氯化物通道的茚满氧基乙酸阻滞剂。
Cas No.54197-31-8
别名R-(+)-甲基吲唑酮,R(+)-IAA 94
化学名2-[[(2R)-6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl]oxy]-acetic acid
Canonical SMILESClC1=C(C([C@](C2CCCC2)(C)C3)=O)C3=CC(OCC(O)=O)=C1Cl
分子式C17H18Cl2O4
分子量357.2
溶解度≤15mg/ml in ethanol;15mg/ml in DMSO;15mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

R(+)-IAA-94 is a potent indanyloxyacetic acid blocker of epithelial chloride channels.IC50 value:Target: IAA-94 has been employed in modulating chloride channel function to probe the dynamics and function of the channels. The high affinity of IAA-94 for the chloride channel has been exploited for isolation and reconstitution of these proteins.

References:
[1]. Landry DW, et al. Epithelial chloride channel. Development of inhibitory ligands. J Gen Physiol. 1987 Dec;90(6):779-98.
[2]. Landry DW, et al. Purification and reconstitution of chloride channels from kidney and trachea. Science. 1989 Jun 23;244(4911):1469-72.
[3]. Weber-Schurholz S, et al. Indanyloxyacetic acid-sensitive chloride channels from outer membranes of skeletal muscle. J Biol Chem. 1993 Jan 5;268(1):547-51.