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4-CPPC
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
4-CPPC图片
CAS NO:29553-70-6
包装与价格：
包装价格(元)
500 μg电议
1mg电议
5mg电议
10mg电议

产品介绍
A MIF-2 inhibitor
Cas No.29553-70-6
Canonical SMILESOC(C1=NC=C(C(O)=O)C(C2=CC=CC(C(O)=O)=C2)=C1)=O
分子式C14H9NO6
分子量287.2
溶解度DMSO: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

4-CPPC is an inhibitor of macrophage migration inhibitory factor-2 (MIF-2; IC50= 27 µM).1It is selective for MIF-2 over MIF-1 (IC50= 450 µM). It inhibits MIF-2, but not MIF-1, binding to CD74in vitrowhen used at a concentration of 10 µM. 4-CPPC (5, 10, and 25 µM) inhibits MIF-2-induced ERK1/2 phosphorylation in primary human skin fibroblasts.

1.Tilstam, P.V., Pantouris, G., Corman, M., et al.A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activityJ. Biol. Chem.294(49)18522-18531(2019)