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Norfluoxetine(hydrochloride)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Norfluoxetine(hydrochloride)图片
CAS NO:57226-68-3
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Norfluoxetine (hydrochloride) 是氟西汀的活性 N-去甲基化代谢物。
Cas No.57226-68-3
别名去甲氟西汀,Desmethylfluoxetine
化学名γ-[4-(trifluoromethyl)phenoxy]-benzenepropanamine, monohydrochloride
Canonical SMILESNCCC(C1=CC=CC=C1)OC2=CC=C(C(F)(F)F)C=C2.Cl
分子式C16H16F3NO•HCl
分子量331.8
溶解度30mg/mL in ethanol, 30mg/mL in DMSO, 30mg/mL in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Norfluoxetine is an active metabolite of the antidepressant fluoxetine that inhibits serotonin uptake with a pKi value of 7.35 [1] . The S-enantiomer of norfluoxetine has 20-times higher serotonin reuptake blocking potency than the R-enantiomer (pKis = 7.86 versus 6.51, respectively).[1][2]

Reference:
[1]. Wong, D.T., Bymaster, F.P., Reid, L.R., et al. Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain. Neuropsychopharmacology 8(4), 337-344 (1993).
[2]. Hiemke, C., and Hartter, S. Pharmacokinetics of selective serotonin reuptake inhibitors. Pharmacology & Therapeutics 85(1), 11-28 (2000).