| CAS NO: | 662164-09-2 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 25mg | 电议 |
| Cas No. | 662164-09-2 |
| 别名 | 2-甲氧基-4-(4-甲基哌嗪-1-基)苯胺,(D3-βArr;NCGC-00379308;NCGC 00379308) |
| 化学名 | N-(1-phenylethyl)-2-(1-piperazinyl)-4-quinazolinamine |
| 分子式 | C20H23N5 |
| 分子量 | 333.439 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | A potent, functionally selective TSH receptor (TSHR) positive allosteric modulator with EC50 of 11.6 uM (β-Arr 1 translocation); does not activate β-Arr 1 translocation to the GLP1R, binds and activates the TSHR and has no agonistic effect on cAMP production nor inhibit TSH-induced cAMP production in DiscoverX1 cells and primary cultures of human thyrocytes; potentiates TSH-induced upregulation of ALPL and OPN mRNA levels, and increases TSH-induced secretion of OPN protein; potentiates the effect of TSH to enhance differentiation of a human preosteoblast in an in vitro model Reference: |
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