NDI-091143 (NDI091143) is a novel and potent inhibitor of human ATP-citrate lyase (ACLY) with anticancer activity. ATP-citrate lyase (ACLY) is a central metabolic enzyme and catalyses the ATP-dependent conversion of citrate and coenzyme A (CoA) to oxaloacetate and acetyl-CoA. The acetyl-CoA product is crucial for the metabolism of fatty acids, the biosynthesis of cholesterol8, and the acetylation and prenylation of proteins.

纯度：≥98%

CAS：2375840-87-0