Isofraxidin

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Isofraxidin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

486-21-5

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
20mg	电议

产品介绍

Isofraxidin 来自 Acanthopanax senticosus 的一种香豆素成分，抑制 MMP-7 表达和人肝癌细胞侵袭。Isofraxidin 作用于肝癌细胞，抑制 ERK1/2 磷酸化。Isofraxidin 减弱 iNOS 和 COX-2 表达，Isofraxidin 还抑制 TLR4/髓样分化蛋白 2 (MD-2) 复合物的形成。

Cas No.	486-21-5
别名	异嗪皮啶
Canonical SMILES	O=C1C=CC2=CC(OC)=C(O)C(OC)=C2O1
分子式	C₁₁H₁₀O₅
分子量	222.19
溶解度	DMSO: 250 mg/mL (1125.16 mM)
储存条件	Store at -20°C,protect from light
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells[1]. Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation[2]. [1]. Yamazaki T, et al. Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits matrix metalloproteinase-7 expression and cell invasion of human hepatoma cells.Biol Pharm Bull. 2010;33(10):1716-22. [2]. Jin J , et al. Isofraxidin targets the TLR4/MD-2 axis to prevent osteoarthritis development.Food Funct. 2018 Nov 14;9(11):5641-5652.