Metaproterenol (hemisulfate) (Orciprenaline hemisulfate) 是一种直接作用的拟交感神经药和 β2-肾上腺素受体 (β2AR) 激动剂，IC50 为 68 nM。
| Cas No. | 5874-97-5 |
| 别名 | 硫酸奥西那林,Orciprenaline hemisulfate |
| Canonical SMILES | OC1=CC(O)=CC(C(CNC(C)C)O)=C1.OC2=CC(O)=CC(C(CNC(C)C)O)=C2.O=S(O)(O)=O |
| 分子式 | C11H17NO3•1/2H2SO4 |
| 分子量 | 260.3 |
| 溶解度 | DMSO: 1 mg/ml,PBS (pH 7.2): 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Metaproterenol is a β2-adrenergic receptor (β2-AR) agonist with bronchodilator actions. It inhibits TGF-α-induced hepatocyte DNA synthesis and proliferation in vitro (IC50 = 15 nM), an effect that is reversed by the β2-AR antagonist butoxamine but not the β1-AR antagonist metoprolol . Metaproterenol dose-dependently relaxes lung strips and increases heart rate and inotropy of right atria and left atria, respectively, isolated from guinea pig (pD2s = 6.4, 7.08, and 6.61, respectively). Formulations containing metaproterenol were previously used as long-acting bronchodilators for the treatment of asthma. |
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