Lefamulin acetate

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Lefamulin acetate

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1350636-82-6

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	电议
5mg	电议
10mg	电议
50mg	电议

产品介绍

Lefamulin acetate (BC-3781 acetate) 是一种口服活性抗生素，用于 community-acquired bacterial pneumonia (CABP) 治疗。Lefamulin acetate (BC-3781 acetate) 是第一种用于人体细菌感染的全身治疗的半合成截短侧耳素。Lefamulin acetate (BC-3781 acetate) 通过与 50S 细菌核糖体的肽基转移酶 peptidyl transferase 中心结合来抑制蛋白质合成，从而阻止了转移RNA与肽转移的结合。

Cas No.	1350636-82-6
别名	醋酸来法莫林,BC-3781 acetate
Canonical SMILES	CC(O)=O.C[C@@H]1C23[C@](C(CC3)=O)([H])C([C@H](OC(CS[C@H]4[C@@H](C[C@H](N)CC4)O)=O)C[C@](C=C)(C)[C@H]1O)([C@H](C)CC2)C
分子式	C₃₀H₄₉NO₇S
分子量	567.78
溶解度	DMSO: ≥ 100 mg/mL (176.12 mM); Water:< 0.1 mg/mL (insoluble)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Lefamulin acetate (BC-3781 acetate) is an orally active antibiotic for community-acquired bacterial pneumonia (CABP) treatment. Lefamulin acetate (BC-3781 acetate) is the first semi-synthetic pleuromutilin for systemic treatment of bacterial infections in humans. Lefamulin acetate (BC-3781 acetate) inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, preventing the binding of transfer RNA for peptide transfer[1]. [1]. Veve MP, et al. Lefamulin: Review of a Promising Novel Pleuromutilin Antibiotic. Pharmacotherapy. 2018 Sep;38(9):935-946. doi: 10.1002/phar.2166. Epub 2018 Aug 20.