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(R)-(+)-Etomoxir sodium salt
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(R)-(+)-Etomoxir sodium salt图片
CAS NO:828934-41-4
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
10mg电议
50mg电议
500mg电议
1g电议

产品介绍
Etomoxir((R)-(+)-Etomoxir) 钠盐是肉碱棕榈酰转移酶 1a (CPT-1a) 的不可逆抑制剂，通过 CPT-1a 抑制脂肪酸氧化 (FAO) 并抑制棕榈酸盐 β-在人、大鼠中的氧化和豚鼠。
Cas No.828934-41-4
别名(R)-(+)-乙莫克舍钠盐,(R)-(+)-Etomoxir sodium salt
化学名sodium (R)-2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylate
Canonical SMILESClC1=CC=C(C=C1)OCCCCCC[C@@]2(C([O-])=O)OC2.[Na+]
分子式C15H18ClNaO4
分子量320.74
溶解度≥ 12mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Etomoxir sodium salt ((R)-(+)-Etomoxir sodium salt) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.

References:
[1]. Agius L, et al. Differences between human, rat and guinea pig hepatocyte cultures. A comparative study of their rates of beta-oxidation and esterification of palmitate and their sensitivity to R-etomoxir. Biochem Pharmacol. 1991 Oct 9;42(9):1711-5.
[2]. O'Connor RS, et al. The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations. Sci Rep. 2018 Apr 19;8(1):6289.