| CAS NO: | 675576-97-3 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 2mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 581.49 |
|---|---|
| Formula | C30H30Cl2N4O4 |
| CAS No. | 675576-97-3 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 100 mg/mL (172.0 mM) |
| Water:<1 mg/mL (slightly soluble or insoluble) | |
| Ethanol: 100 mg/mL (172.0 mM) | |
| Synonyms | Nutlin3b; Nutlin 3b; Nutlin-3b |
| Chemical Name | 2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]- |
| In Vitro | Nutlin-3a induces the expression of MDM2 and p21 (but not p53) only in cells with wild-type p53. Nutlin-3b has no effect regardless of the p53 status of the cells. Only the active enantiomer Nutlin-3a shows a potent antiproliferative activity and clear separation of potency between the cells harboring wild-type p53 and those harboring mutant p53. The potency of Nutlin-3b is much lower in the wild-type p53 cells and nearly identical to the potency of Nutlin-3a against the mutant p53 cells. After 48 hours of exposure to the Nutlin-3a, 45% of the cell population became TUNEL positive, but cells treated with the Nutlin-3b are indistinguishable from the untreated controls. |
|---|---|
| In Vivo | N/A |
| Animal model | N/A |
| Formulation & Dosage | N/A |
| References | [1] Vassilev LT, et al. Science, 2004, 303(5659), 844-848. |
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