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5(S)-HETE-d8
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
5(S)-HETE-d8图片
CAS NO:330796-62-8
包装与价格：
包装价格(元)
25 μg电议
50 μg电议
100 μg电议

产品介绍
An internal standard for the quantification of 5-HETE
Cas No.330796-62-8
Canonical SMILESCCCCC/C([2H])=C([2H])\C/C([2H])=C([2H])\C/C([2H])=C([2H])\C=C([2H])\[C@@]([2H])(O)CCCC(O)=O
分子式C20H24D8O3
分子量328.5
溶解度0.1 M Na2CO3: 2 mg/ml,DMF: Miscible,DMSO: Miscible,Ethanol: Miscible,PBS pH 7.2: 0.8 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

5(S)-HETE-d8contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of 5(S)-HETE by GC-or LC-mass spectrometry (MS). 5(S)-HETE is produced by the action of 5-lipoxygenase on arachidonic acid to give 5(S)-HpETE, followed by reduction of the hydroperoxide. 5(S)-HETE has proliferative and chemotactic effects on granulocytes.1When further metabolized to the 5-oxoETE, it is a more potent eosinophil chemoattractant than leukotriene B4.2,3

1.Schwenk, U., and SchrÖder, J.M.5-Oxo-eicosanoids are potent eosinophil chemotactic factors. Functional characterization and structural requirementsJ. Biol. Chem.270(25)15029-15036(1994) 2.Powell, W.S., Gravelle, F., and Gravel, S.Metabolism of 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid and other 5(S)-hydroxyeicosanoids by a specific dehydrogenase in human polymorphonuclear leukocytesJ. Biol. Chem.267(27)19233-19241(1992) 3.Dodge, W., and Thomas, M.The effect of 5-hydroxyeicosatetraenoic acid on the proliferation of granulocyte progenitors and embryonic fibroblasts of the chickBiochem. Biophys. Res. Commun.131(2)731-735(1985)