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Benzonatate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Benzonatate图片
CAS NO:104-31-4
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
苯佐那酯 (Benzononatine) 是一种外周口服镇咳药，可抑制咳嗽牵张感受器的活性。
Cas No.104-31-4
别名苯佐那酯,Benzononatine
化学名4-(butylamino)-benzoic acid, 3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yl ester
Canonical SMILESO=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCOC)C1=CC=C(NCCCC)C=C1
分子式C30H53NO11
分子量603.8
溶解度DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Benzonatate is a reversible voltage-gated sodium channel blocker.[1] It blocks Nav1.7 currents in a concentration- and voltage-dependent manner (IC50s = 5.9 and 1.4 μM at holding potentials of -100 and -70 mV, respectively) and inhibits action potential firing in catecholamine A differentiated (CAD) cells. Benzonatate also blocks 80% of Nav1.3 currents in N1E-115 cells when used at a concentration of 100 μM. In vivo, benzonatate (0.85 mg/min) reduces the frequency, but has no effect on the amplitude, of the cough reflex in anesthetized dogs.[2] Formulations containing benzonatate have been used as antitussive agents for the treatment of coughs.

Reference:
[1]. Evans, M.S., Maglinger, G.B., and Fletcher, A.M. Benzonatate inhibition of voltage-gated sodium currents. Neuropharmacology 101, 179-187 (2016).
[2]. Yanaura, S., Hosokawa, T., Kitagawa, H., et al. Effects of peripheral airway response on the cough reflex (author’s transl). Nihon Yakurigaku Zasshi. 76(8), 709-716 (1980).