N-desmethyl Bendamustine is an active metabolite of the DNA alkylating agent bendamustine.
| Cas No. | 41515-13-3 |
| 别名 | 盐酸苯达莫司汀乙酯水解杂质 |
| Canonical SMILES | ClCCN(CCCl)C1=CC=C(N=C(CCCC(O)=O)N2)C2=C1 |
| 分子式 | C15H19Cl2N3O2 |
| 分子量 | 344.2 |
| 溶解度 | Acetonitrile:Methanol (1:1): soluble,DMSO: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | N-desmethyl Bendamustine is an active metabolite of the DNA alkylating agent bendamustine . N-desmethyl Bendamustine is formed through demethylation of the benzimidazole ring in bendamustine by the cytochrome P450 (CYP) isoform CYP1A2. It inhibits proliferation of non-cancerous peripheral blood leukocytes (PBLs; IC50 = 45 µM) and SU-DHL-1, SU-DHL-9, and Daudi lymphoma cells (IC50s = 270, 170, and 120 µM, respectively). |
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