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15-deoxy-𗉜,14-Prostaglandin J2-d4
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
15-deoxy-𗉜,14-Prostaglandin J2-d4图片
CAS NO:1542166-82-4
包装与价格：
包装价格(元)
25 μg电议
50 μg电议
100 μg电议

产品介绍
An internal standard for the quantification of 15deoxyΔ12,14prostaglandin J2
Cas No.1542166-82-4
别名15d-PGJ2-d4; 15-Deoxy-Δ12,14-PGJ2-d4
Canonical SMILESO=C1/C([C@@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)C=C1)=C/C=C/CCCCC
分子式C20H24D4O3
分子量320.5
溶解度DMF: >100 mg/ml (from PGD2),DMSO: >50 mg/ml (from PGD2),Ethanol: >75 mg/ml (from PGD2),PBS pH 7.2: >2.7 mg/ml (from 15-deoxy-d12,
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

15-deoxy-δ12,14-PGJ2-d4contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 15-deoxy-δ12,14-PGJ2by GC-or LC-mass spectrometry. 15-deoxy-δ12,14-Prostaglandin J2(15-deoxy-δ12,14-PGJ2) is a metabolite of PGJ2. 15-deoxy-δ12,14-PGJ2is formed from PGD2by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50of 2 µM in a murine chimera system.1,215-deoxy-δ12,14-PGJ2is more potent than PGD2, δ12-PGJ2, and PGJ2in stimulating lipogenesis in C3H10T1/2 cells. The EC50for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.1

1.Forman, B.M., Tontonoz, P., Chen, J., et al.15-Deoxy-δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγCell83(5)803-812(1995) 2.Kliewer, S.A., Lenhard, J.M., Willson, T.M., et al.A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiationCell83(5)813-819(1995)