| CAS NO: | 1011557-82-6 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 2mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 454.63 |
|---|---|
| Formula | C25H34N4O2S |
| CAS No. | 1011557-82-6 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 98 mg/mL (215.55 mM) |
| Water:<1 mg/mL (slightly soluble or insoluble) | |
| Ethanol: <1 mg/mL (slightly soluble or insoluble) | |
| Solubility (In vivo) | Tenovin-6; Tenovin 6; Tenovin6 |
| General | Tenovin-6 is a more water-soluble analog of tenovin-1. Tenovin-6 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 of 21 μM, 10 μM, and 67 μM, respectively. |
|---|---|
| Animal model | ARN8 melanoma cells were injected into the flank of SCID mice and allowed to develop into tumors. |
| Formulation | |
| Dosages | 50 mg/kg |
| Administration | i.p. |
| References | [1] Lain S, et al. Cancer Cell, 2008, 13(5), 454-463. |
 Tenovin-6 Delays Tumor Growth In Vivo. Lain S, et al. Cancer Cell, 2008, 13(5), 454-463. |  Tenovin-6 Inhibits the Protein Deacetylase Activities of Purified Sirtuins SirT1 and SirT2 |
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