[登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > Stearoyl-L-carnitine(chloride)
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Stearoyl-L-carnitine(chloride)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Stearoyl-L-carnitine(chloride)图片
CAS NO:32350-57-5
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
硬脂酰左旋肉碱（氯化物）是一种内源性长链酰基肉碱。
Cas No.32350-57-5
别名C18 Carnitine
化学名3-carboxy-N,N,N-trimethyl-2R-[(1-oxooctadecyl)oxy]-1-propanaminium, monochloride
Canonical SMILESOC(C[C@H](C[N+](C)(C)C)OC(CCCCCCCCCCCCCCCCC)=O)=O.[Cl-]
分子式C25H50NO4•Cl
分子量464.1
溶解度DMF: 20 mg/ml,DMSO: 14 mg/ml,Ethanol: 20 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Stearoyl-L-carnitine is a naturally occurring long-chain acylcarnitine [1]. It inhibits sodium-dependent [3H]carnitine uptake in human proximal convoluted tubular (HPCT) cells by 52% when used at a concentration of 500 μM [2] It also inhibits lecithin:cholesterol acyltransferase activity in rat, but not human, plasma when used at a concentration of 500 μM/ml of plasma. [3] Plasma levels of stearoyl-L-carnitine are decreased in patients with chronic fatigue syndrome and increased in patients with end-stage renal disease.[1][4]

Reference:
[1]. Reuter, S.E., Evans, A.M., Faull, R.J., et al. Impact of haemodialysis on individual endogenous plasma acylcarnitine concentrations in end-stage renal disease. Ann. Clin. Biochem. 42(Pt 5), 387-393 (2005).
[2]. Huang, W., Shaikh, S.N., Ganapathy, M.E., et al. Carnitine transport and its inhibition by sulfonylureas in human kidney proximal tubular epithelial cells. Biochem. Pharmacol. 58(8), 1361-1370 (1999).
[3]. Bell, F.P. Carnitine esters: Novel inhibitors of plasma lecithin: Cholesterol acyltransferase in experimental animals but not in man (Homo sapiens). Int. J. Biochem. 15(2), 133-136 (1983).
[4]. Reuter, S.E., and Evans, A.M. Long-chain acylcarnitine deficiency in patients with chronic fatigue syndrome. Potential involvement of altered carnitine palmitoyltransferase-I activity. J. Intern. Med. 270(1), 76-84 (2011).