| CAS NO: | 71555-25-4 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 234.32 |
|---|---|
| Formula | C11H14N4S |
| CAS No. | 71555-25-4 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 19 mg/mL (81.08 mM) |
| Water:<1 mg/mL (slightly soluble or insoluble) | |
| Ethanol: <1 mg/mL | |
| Synonyms | NSC319726; NSC-319726; NSC 319726 |
| General | NSC319726 (5mg/kg, 7days) exhibits greater toxicity for p53(R172H/R172H) mice, with only 30% survival, as compared to 100% survival for p53+/+ and p53-/- mice. NSC319726 inhibits the growth of TOV112D-p53(R175H) xenografts, but not H460 (p53+/+) and MDAMB468-p53(R273W) xenografts. |
|---|---|
| Animal model | p53+/+, p53-/- and p53R172H knockin mice |
| Formulation | DMSO |
| Dosages | 5-10 mg/kg/day, up to 7 days |
| Administration | i.p. |
| References | [1] Yu X, et al. Cancer Cell, 2012, 21(5), 614-625. |
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