gamma-Mangostin

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gamma-Mangostin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

31271-07-5

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议
20mg	电议

产品介绍

Gamma-Mangostin 是一种新颖的竞争性 5-HT2A receptors 拮抗剂，从药用植物 Garcinia mangostana 的果壳中提纯。Gamma-Mangostin 是一种运甲状腺素蛋白 (TTR) 原纤维化抑制剂，它与甲状腺素 (T4) 结合位点结合并稳定了 TTR 四聚体。Gamma-Mangostin 抑制 [3H]-spiperone 与培养的大鼠主动脉心肌细胞结合 (IC50 = 3.5 nM)，并降低大鼠冠状动脉对 5-HT2A 的灌注压力反应 (IC50 = 0.32 µM)。

Cas No.	31271-07-5
别名	γ-倒捻子素,γ-Mangostin
Canonical SMILES	O=C1C2=C(OC3=C1C(C/C=C(C)\C)=C(O)C(O)=C3)C=C(O)C(C/C=C(C)\C)=C2O
分子式	C₂₃H₂₄O₆
分子量	396.43
溶解度	DMSO: 250 mg/mL (630.63 mM)
储存条件	Store at 2-8°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptors antagonist, purified from the fruit hull of the medicinal plant Garcinia mangostana. Gamma-Mangostin is a inhibitor of Transthyretin (TTR) fibrillization, it binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer[2]. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 µM) [1]. [1]. Chairungsrilerd N, et al. Gamma-mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):25-31. [2]. Yokoyama T, et al. Discovery of γ-Mangostin as an Amyloidogenesis Inhibitor. Sci Rep. 2015 Aug 27;5:13570.