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SB 215505
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
SB 215505图片
CAS NO:162100-15-4
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
SB 215505 是一种有效的亚型选择性 5-HT2B 受体拮抗剂，对 5-HT2B、5-HT2A、5-HT2C 的 pKi 值分别为 8.3、6.77、7.66。
Cas No.162100-15-4
别名6-氯-2,3-二氢-5-甲基-N-5-喹啉基-1H-吲哚-1-甲酰胺
Canonical SMILESO=C(NC3=CC=CC4=C3C=CC=N4)N(CC2)C1=C2C=C(C)C(Cl)=C1
分子式C19H16ClN3O
分子量337.81
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent 5-HT2B/2C receptor antagonist (pKi values are 8.3, 7.66 and 6.77 for 5-HT2B, 5-HT2C and 5-HT2A respectively). Increases wakefulness and motor activity in rats. Orally active.

Kennett et al (1998) Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated. Neuropharmacology 37 1603 PMID:9886683 |Reavill et al (1999) Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. Br.J.Pharmacol. 126 572 PMID:10188965 |Kantor et al (2004) Increased wakefulness, motor activity and decreased theta activity after blockade of the 5-HT2B receptor by the subtype-selective antagonist SB-215505. Br.J.Pharmacol. 142 1332 PMID:15265808