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6-Thioinosine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
6-Thioinosine图片
CAS NO:574-25-4
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
6-?Thioinosine (6TI) 是一种嘌呤抗代谢物，为抗脂肪形成剂，能够降低 PPAR γ 和 C/EBPα 及其目标基因 LPL，CD36，aP2 和 LXRα 的 mRNA 水平。
Cas No.574-25-4
别名6-疏基嘌呤核苷,6TI; 6-Mercaptopurine riboside
Canonical SMILESS=C1NC=NC2=C1N=CN2C3[C@@H]([C@@H]([C@@H](CO)O3)O)O
分子式C10H12N4O4S
分子量284.29
溶解度DMSO: 50 mg/mL (175.88 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

6-?Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα[1][2].

[1]. Lee J, et al. Anti-adipogenesis by 6-thioinosine is mediated by downregulation of PPAR gamma through JNK-dependent upregulation of iNOS. Cell Mol Life Sci. 2010 Feb;67(3):467-81. [2]. Neubert D, et al. Interference of 6-mercaptopurine riboside, 6-methylmercaptopurine riboside and azathioprine with the morphogenetic differentiation of mouse extremities in vivo and in organ culture. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):93-105.