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tetranor-PGEM-d6
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
tetranor-PGEM-d6图片
CAS NO:1240398-16-6
包装与价格：
包装价格(元)
25 μg电议
50 μg电议
100 μg电议

产品介绍
An internal standard for the quantification of tetranorPGEM
Cas No.1240398-16-6
Canonical SMILESO=C1[C@H](CCC(O)=O)[C@@H](CCC(CC([2H])([2H])C([2H])([2H])C([2H])([2H])C(O)=O)=O)[C@H](O)C1
分子式C16H18D6O7
分子量334.4
溶解度DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: Not Stable,PBS (pH 7.2): 1 mg/ml
储存条件Store at -80°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tetranor prostaglandin E metabolite-d6(tetranor-PGEM-d6) contains six deuterium atoms at the 13, 13, 14, 14, 15, and 15 positions. It is intended for use as an internal standard for the quantification of tetranor PGEM by GC-or LC-mass spectrometry. Tetranor PGEM-d6is the major urinary metabolite of PGE1and PGE2. It is used as a urinary marker of PGE2biosynthesis, and to monitor metabolism after infusion or injection of PGE1as a pharmaceutical.1,2Normal healthy males excrete 16-30 µg of tetranor PGEM over a 24-hour period. Females excrete less by about a factor of three. Following oral administration (4 x 50 mg/24 hours) of the COX inhibitor, indomethacin, urinary levels of tetranor PGEM decrease by 75-98% indicating the almost complete loss of PGE2biosynthesis.1

1.Hamberg, M.Inhibition of prostaglandin synthesis in manBiochemical and Biophysical Research Communications49720-726(1972) 2.Honda, H., Fukawa, K., and Sawabe, T.Influence of adjuvant arthritis on main urinary metabolites of prostaglandin F and E ratsProstaglandins19259-269(1980)