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WAY 181187 oxalate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
WAY 181187 oxalate图片
CAS NO:1883548-85-3
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
WAY-181187 (SAX-187) oxalate 是一种有效的选择性全 5-HT6 受体激动剂，Ki 为 2.2 nM，EC50 为 6.6 nM。
Cas No.1883548-85-3
别名SAX-187 oxalate
Canonical SMILESNCCC2=CN(S(C3=C(Cl)N=C4N3C=CS4)(=O)=O)C1=CC=CC=C12.O=C(O)C(O)=O
分子式C15H13ClN4O2S2.C2H2O4
分子量470.91
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

High affinity and selective 5-HT6 agonist (Ki = 2.2 nM). Displays 60-fold selectivity over other 5-HT and monoamine receptors. Increases firing rate of 5-HT neurons. Modifies sleep and wakefulness profiles following direct injections into the dorsal raphe nucleus, in vivo. Orally bioavailable.

Brouard et al (2015) Pharmacological evidence for 5-HT6 receptor modulation of 5-HT neuron firing in Vivo. ACS Chem.Neurosci. 6 1241 PMID:25837696 |Cole et al (2007) Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT6 receptor agonist. J.Med.Chem. 50 5535 PMID:17948978