| Cas No. | 69304-49-0 |
| 别名 | (E)-5-(2-溴乙烯基)-2-脱氧尿苷 |
| Canonical SMILES | O=C1NC(NC=C1/C=C/Br)=O |
| 分子式 | C6H5BrN2O2 |
| 分子量 | 217 |
| 溶解度 | DMF: 60 mg/mL,DMSO: 53 mg/mL,Ethanol: 0.8 mg/mL,PBS (pH 7.2): 8 mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 µmol/kg, increasing survival time. |
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