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LY2857785
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LY2857785图片
CAS NO:1619903-54-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品名称
LY-2857785, LY 2857785
产品介绍

生物活性

LY2857785是一种有效的选择性CDK9抑制剂。显着降低RNA聚合酶II CTD的磷酸化并显着降低MCL1蛋白水平,从而导致多种白血病和实体瘤细胞系发生凋亡。

化学数据

目录号A15823
作用机制Inhibitor (抑制剂)
M. Wt448.6
FormulaC26H36N6O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1619903-54-6
SynonymsLY-2857785, LY 2857785
SMILESCC(C)C1=C2C=C(C=CC2=NN1C)C3=NC(=NC=C3)NC4CCC(CC4)NC5CCOCC5

溶解度

In vitroDMSO22 mg/mL (49.04 mM)
WaterInsoluble
Ethanol40 mg/mL (89.16 mM)
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM22.29 mL111.46 mL222.92 mL
0.5 mM4.46 mL22.29 mL44.58 mL
1 mM2.23 mL11.15 mL22.29 mL
5 mM0.45 mL2.23 mL4.46 mL

*The above data is based on the productmolecular weight 448.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.