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CBR-470-2
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CBR-470-2图片
CAS NO:2416095-00-4
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
CBR-470-2是甘氨酸取代的类似物，可以激活NRF2信号传导。CBR-470-2可用于调节糖酵解。
Cas No.2416095-00-4
Canonical SMILESOC(CN[C@@H](C1)[C@@H](S(C2=CC=C(Cl)C(Cl)=C2)(=O)=O)CS1(=O)=O)=O
分子式C12H13Cl2NO6S2
分子量402.27
溶解度DMSO: 200 mg/mL (497.18 mM)
储存条件4℃, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CBR-470-2, a glycine-substituted analog, can activate NRF2 signaling. CBR-470-2 can be used for the research of modulation glycolysis[1].

CBR-470-2 (1-10 μM; 24 h) increases transcript levels of the NRF2-responsive genes NQO1 and HMOX1 in epidermal keratinocytes and dermal fibroblasts[1].

CBR-470-2 (50 mg/kg; p.o. twice daily for 10 d) induces activation of NRF2 signaling in vivo[1]. Animal Model: Balb/C mice (5-week old) are exposed to UVB[1]

[1]. Bollong MJ, et, al. A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. Nature. 2018 Oct;562(7728):600-604.