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L-Methionine-(S,R)-Sulfoximine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-Methionine-(S,R)-Sulfoximine图片
CAS NO:15985-39-4
包装与价格:
包装价格(元)
50mg电议
100mg电议
500mg电议
1g电议

产品介绍
L-Methionine-(S,R)-Sulfoximine (MSX) 是谷氨酰胺合成酶的抑制剂。
Cas No.15985-39-4
别名L-蛋氨酸磺酸盐,MSX; MSO
Canonical SMILESN[C@H](C(O)=O)CCS(C)(=N)=O
分子式C5H12N2O3S
分子量180.2
溶解度PBS (pH 7.2): 5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

L-Methionine-(S,R)-sulfoximine is an inhibitor of glutamine synthetase and a sulfoximine derivative of L-methionine.1 It inhibits pea glutamine synthetase by 31 to 64% when used at concentrations ranging from 5 to 25 μM following preincubation with L-glutamine, an effect that is absent without L-glutamine preincubation. It also inhibits glutamine synthetase in isolated chick embryo retinas.2

References
1. Sinden, S.L., and Durbin, R.D. Glutamine synthetase inhibition: Possible mode of action of wildfire toxin from Pseudomonas tabaci. Nature 219(5152), 379-380 (1968).
2. Reif-Lehrer, L., and Coghlin, J. Conversion of glutamic acid to glutamine by retinal glutamine synthetase. Exp. Eye. Res. 17(4), 321-328 (1973).