| CAS NO: | 1185132-92-6 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 1185132-92-6 |
| 别名 | 诺氟西汀-D5 |
| Canonical SMILES | FC(F)(F)C(C=C1)=CC=C1OC(C2=CC=CC=C2)([2H])C([2H])([2H])C([2H])([2H])N.Cl |
| 分子式 | C16H11D5F3NO·HCl |
| 分子量 | 336.8 |
| 溶解度 | Chloroform: slightly soluble,DMSO: slightly soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Norfluoxetine-d5is intended for use as an internal standard for the quantification of norfluoxetine by GC- or LC-MS. Norfluoxetine is an active metabolite of the antidepressant fluoxetine.1It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A.2Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki= 44.7 nM) and isolated human platelets (IC50= ~15 nM).1It has been found in the tissues of fish exposed to wastewater effluent.3 1.Wong, D.T., Bymaster, F.P., Reid, L.R., et al.Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brainNeuropsychopharmacology8(4)337-344(1993) 2.Hiemke, C., and HÄrtter, S.Pharmacokinetics of selective serotonin reuptake inhibitorsPharmacol. Ther.85(1)11-28(2000) 3.Brooks, B.W., Chambliss, C.K., Stanley, J.K., et al.Determination of select antidepressants in fish from an effluent-dominated streamEnviron. Toxicol. Chem.24(2)464-469(2005) |
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