| CAS NO: | 4608-49-5 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| Cas No. | 4608-49-5 |
| Canonical SMILES | C[C@]12[C@@](C(C)(CCC2)C)([H])[C@H](CC([C@@H]1CC[C@](C)(O)C=C)=C)OC(C)=O |
| 分子式 | C22H36O3 |
| 分子量 | 348.5 |
| 溶解度 | Chloroform: slightly soluble,Ethyl Acetate: slightly soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Larixyl acetate is a diterpenoid that has been found inLarixand has transient receptor potential canonical 6 (TRPC6) inhibitory and analgesic activities.1,2It inhibits the activity of TRPC6 (IC50= 0.58 µM) and is selective for TRPC6 over TRPC3 (IC50= 6.83 µM), as well as over nine additional TRP channels at 10 µM.1Intrathecal administration of larixyl acetate reduces mechanical and cold allodynia in a rat model of neuropathic pain induced by spared nerve injury (SNI). 1.Urban, N., Wang, L., Kwiek, S., et al.Identification and validation of larixyl acetate as a potent TRPC6 inhibitorMol. Pharmacol.89(1)197-213(2016) 2.Wang, J., Zhao, M., Jia, P., et al.The analgesic action of larixyl acetate, a potent TRPC6 inhibitor, in rat neuropathic pain model induced by spared nerve injuryJ. Neuroinflammation17(1)118(2020) |
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