1-Octen-3-ol is a volatile organic compound (VOC) that has been found in fungi and plants.¹It has also been found in oxen breath and human sweat and is an attractant forOchlerotatus,Psorophora,Anopheles, andCoquillettidiamosquitoes but a repellant forCulexmosquitoes.^1,21-Octen-3-ol (3 and 10 ppm) inhibits dopamine uptake in HEK cells expressing the human dopamine transporter (HEK-DAT cells).³It induces dopaminergic neuron loss and locomotor deficits in, as well as reduces survival of,D. melanogasterwhen administeredviainhalation at a dose of 0.5 ppm.

1.Xu, P., Zhu, F., Buss, G.K., et al.1-Octen-3-ol ? the attractant that repelsF1000Res.4156(2015) 2.Kline, D.L., Allan, S.A., Bernier, U.R., et al.Evaluation of the enantiomers of 1-octen-3-ol and 1-octyn-3-ol as attractants for mosquitoes associated with a freshwater swamp in Florida, U.S.AMed. Vet. Entomol.21(4)323-331(2007) 3.Inamdar, A.A., Hossain, M.M., Bernstein, A.I., et al.Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegenerationProc. Natl. Acad. Sci. USA110(48)19561-19566(2013)