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1-Carboxycyclohexaneacetic Acid
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAS NO:67950-95-2
包装与价格：
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
A potential impurity in commercial preparations of gabapentin
Cas No.67950-95-2
别名加巴喷丁杂质E
Canonical SMILESO=C(CC1(CCCCC1)C(O)=O)O
分子式C9H14O4
分子量186.2
溶解度DMF: 20 mg/mL,DMSO: 33 mg/mL,Ethanol: 25 mg/mL,PBS (pH 7.2): 0.16 mg/mL
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

1-Carboxycyclohexaneacetic acid is a potential impurity in commercial preparations of the antiepileptic gabapentin.1It has also been used as a precursor in the synthesis of antagonists of the serotonin (5-HT) receptor subtype 5-HT2A.2

1.Ragham, P.K., and Chandrasekhar, K.B.Development and validation of a stability-indicating RP-HPL C-CAD method for gabapentin and its related impurities in presence of degradation productsJ. Pharm. Biomed. Anal.125122-129(2016) 2.Obniska, J., Pawlowski, M., Kolaczkowski, M., et al.Synthesis and 5-HT1A/5-HT2A receptor activity of new N-[3-(4-phenylpiperazin-1-yl)-propyl] derivatives of 3-spiro-cyclohexanepyrrolidine-2,5-dione and 3-spiro-beta-tetralonepyrrolidine-2,5-dionePol. J. Pharmacol.55(4)553-557(2003)