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Estrone 3-methyl ether
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Estrone 3-methyl ether图片
CAS NO:1624-62-0
包装与价格：
包装价格(元)
500mg电议
1g电议
5g电议
10g电议

产品介绍
 
Cas No.1624-62-0
别名3-甲氧基雌酮
Canonical SMILESO=C1CC[C@@]2([H])[C@]3([H])CCC4=CC(OC)=CC=C4[C@@]3([H])CC[C@@]21C
分子式C19H24O2
分子量284.4
溶解度Chloroform: 30 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Estrone 3-methyl ether is a synthetic estrogen and derivative of estrone .1 It stimulates proliferation of estrogen-dependent MCF-7 breast cancer cells in vitro when used at concentrations ranging from 0.16 to 20 μM but lacks estrogen receptor (ER) binding activity (IC50s = >100 μM for ERα and ERβ). Estrone 3-methyl ether has been used in the synthesis of various estrogen receptor modulators.2

References
1. Alsayari, A., Kopel, L., Ahmed, M.S., et al. Design, synthesis, and biological evaluation of steroidal analogs as estrogenic/anti-estrogenic agents. Steroids 118, 32-40 (2017).
2. Kuznetsov, Y.V., Levina, I.S., Scherbakov, A.M., et al. New estrogen receptor antagonists. 3,20-Dihydroxy-19-norpregna-1,3,5(10)-trienes: Synthesis, molecular modeling, and biological evaluation. Eur. J. Med. Chem. 143, 670-682 (2018).