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ABC99
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
ABC99图片
CAS NO:2331255-53-7
包装与价格：
包装价格(元)
500μg电议
1mg电议
5mg电议

产品介绍
ABC99 是一种 N-羟基乙内酰脲 (NHH) 氨基甲酸酯，可选择性抑制 Wnt 脱酰酶 NOTUM (IC50=13 nM)。 ABC99 在 NOTUM 存在的情况下保留 Wnt3A 信号。
Cas No.2331255-53-7
化学名7-(4-chlorobenzyl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl-2,3-dihydro-4H-benzo[b][1,4]oxazine-4-carboxylate
Canonical SMILESClC1=CC=C(CN2CC(C(N(OC(N3C(C=CC=C4)=C4OCC3)=O)C5=O)=O)N5CC2)C=C1
分子式C22H21ClN4O5
分子量456.9
溶解度1mg/mL in Chloroform, 1mg/mL in acetonitrile, 1mg/mL in methyl acetate
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ABC99 is an N-hydroxyhydantoin (NHH) carbamate that inhibits the Wnt-deacylating enzyme NOTUM (IC50 = 13 nM).[1] It preserves Wnt3A signaling in the presence of NOTUM (EC50 = 89 nM in a cell-based reporter assay).

Reference:
[1]. Suciu, R.M., Cognetta, A.B., III., Potter, Z.E., et al. Selective irreversible inhibitors of the Wnt-deacylating enzyme NOTUM developed by activity-based protein profiling. ACS Med. Chem. Lett. 9(6), 563-568 (2018).