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RBPJ Inhibitor-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
RBPJ Inhibitor-1图片
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
RBPJInhibitor-1(RIN1)是首个RBPJ抑制剂，可阻断RBPJ和SHARP的相互作用。RBPJInhibitor-1(RIN1)可抑制Notch依赖性的肿瘤细胞的增殖。
别名RIN1
Canonical SMILESO=C(N)C1=CC=C(C2=CC=NN2C)C=C1OC3=CC=CC=C3F
分子式C17H14FN3O2
分子量311.31
溶解度DMSO: 250 mg/mL (803.06 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

RBPJ Inhibitor-1 (RIN1), the first RBPJ inhibitor, blocks the functional interaction of RBPJ with SHARP. RBPJ Inhibitor-1 (RIN1) inhibits NOTCH-dependent tumor cell proliferation[1].

RIN1 inhibits the proliferation of hematologic cancer cell lines and promoted skeletal muscle diferentiation from C2C12 myoblasts[1].RIN1 (0.6 µM, corresponding to 3 × IC50) decreases the number of MHC+ cells and increased the number of nuclei per cell, indicating that it induces the formation of multinucleated myofbers[1]. Cell Viability Assay[1] Cell Line: AD-293 cells were transfected with RBPJ-VP16myc.

[1]. Cecilia Hurtado, et al. Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ. Sci Rep. 2019 Jul 25;9(1):10811.