| CAS NO: | 2444781-71-7 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 200mg | 电议 |
| 500mg | 电议 |
| Cas No. | 2444781-71-7 |
| 别名 | DDD107498 succinate; DDD-498 succinate; M5717 succinate |
| Canonical SMILES | OC(CCC(O)=O)=O.O=C(C1=CC(C2=CC=C(C=C2)CN3CCOCC3)=NC4=CC=C(C=C41)F)NCCN5CCCC5 |
| 分子式 | C31H37FN4O6 |
| 分子量 | 580.65 |
| 溶解度 | DMSO: 135 mg/mL (232.50 mM) |
| 储存条件 | 4°C, away from moisture and light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | DDD107498 succinate (DDD-498 succinate) is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P. falciparum 3D7. DDD107498 succinate inhibits protein synthesis by targeting eEF2/CaMKIII, with an EC50 of 2 nM for WT-PfeEF2[1]. EC50: 1 nM (3D7 parasites), 2 nM (WT-PfeEF2)[1] DDD107498 exhibits an ED90 of 0.57 mg/kg after a single oral dose in mice infected with the rodent parasite P. berghei[1]. [1]. BaragaÑa B, et al. A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature. 2015 Jun 18;522(7556):315-20. |
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